As a way to rationalise the noticed ABL kinase inhibitory success from the 3D structural point of view, the lead compounds I and II, and the newly designed derivatives 4a, 4b, and five have been docked inside the catalytic kinase domains of BCR-ABLWT (PDB code: 3OXZ) and BCR-ABLT315I (PDB code: https://indazoleproducts42075.blogdemls.com/30916797/indazole-nmr-an-overview