There exists a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors within the dorsal horn to minimize afferent pain transmission and produce analgesia. Hence, medication like clonidine that concentrate on alpha-2 receptors can affect the transmission of agony. Can be provided as monotherapy or https://www.proleviate.com/post/the-new-pain-killer-conolidine