Whilst the opiate receptor relies on G protein coupling for signal transduction, this receptor was identified to make the most of arrestin activation for internalization on the receptor. Or else, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable improvement in binding efficacy. https://howtouseconolidine89360.blogocial.com/conolidin-to-replace-traditional-painkillers-fundamentals-explained-74702454